Biological Activity[Des-octanoyl]-Ghrelin (human) is a non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.
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Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.
Baldanzi et al.
J.Cell Biol., 2002;159:1029
Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.
Bedendi et al.
Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor.
Thompson et al.
Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines.
Cassoni et al.
Citation for [Des-octanoyl]-Ghrelin (human)
The citations listed below are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (human) include:
1 Citation: Showing 1 - 1
Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes.
Authors: Rodríguez Et al.
FASEB J 2009;33:541
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