Catalog Number: 2260
Biological Activity
Non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.
Technical Data
  • M.Wt:
    3244.51
  • Formula:
    C141H235N47O41
  • Sequence:
    GSSFLSPEHQRVQQRKESKKPPAKLQPR
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    313951-59-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.
    Baldanzi et al.
    J.Cell Biol., 2002;159:1029
  2. Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.
    Bedendi et al.
    Eur.J.Pharmacol., 2003;476:87
  3. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor.
    Thompson et al.
    Endocrinology, 2004;145:234
  4. Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines.
    Cassoni et al.
    Eur.J.Endocrinol., 2004;150:173
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (human) include:

1 Citations: Showing 1 - 1

  1. Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes.
    Authors: Rodríguez Et al.
    FASEB J 2009;33:541

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