Desmin Antibody (D33)

Novus Biologicals | Catalog # NB120-17156

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # D33
View all Desmin Primary Antibodies »

Product Specifications

Immunogen

BALB/C mice were immunized with purified desmin from human muscle.

Localization

Cytoplasmic

Specificity

This antibody reacts with desmin protein of 53 kDa. Both striated as well as smooth muscle cells stain well with this antibody. The antibody shows a broad interspecific cross-reactivity, reacting with human.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Desmin Antibody (D33)

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - Formalin fixed paraffin embedded human leiomyoma stained with Desmin antibody (NB120-17156).
Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - Paraffin embedded human leiomyoma stained with Desmin antibody.
Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - FFPE human leiomyoma.
Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]
Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]
Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]
Immunohistochemistry: Desmin Antibody (D33) [NB120-17156]
Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156]

Immunohistochemistry-Paraffin: Desmin Antibody (D33) [NB120-17156] - Rat heart tissue, alcohol fixed, paraffin embedded. Image from verified customer review.

Applications for Desmin Antibody (D33)

Application
Recommended Usage

Immunohistochemistry

1:50-1:100

Immunohistochemistry-Paraffin

1:50-1:100
Application Notes
IHC-P: recommended incubation time of 30 min at RT.

Reviewed Applications

Read 1 review rated 5 using NB120-17156 in the following applications:

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Tissue culture supernatant

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Desmin

Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin.

Alternate Names

CMD1I, DES

Entrez Gene IDs

1674 (Human); 64362 (Rat)

Gene Symbol

DES

Additional Desmin Products

Product Documents for Desmin Antibody (D33)

Certificate of Analysis

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Product Specific Notices for Desmin Antibody (D33)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cardiac Stem Cell Markers

Citations for Desmin Antibody (D33)

Customer Reviews for Desmin Antibody (D33) (1)

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  • Desmin Antibody (D33)
    Name: Anonymous
    Application: Immunohistochemistry-Paraffin
    Sample Tested: Heart tissue
    Species: Rat
    Verified Customer | Posted 01/07/2019
    Rat heart tissue - Alcohol-fixed paraffin embedded
    Desmin Antibody (D33) NB120-17156

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Protocols

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