Catalog Number: 2749
Alternate Names: d-Medetomidine hydrochloride
Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Biological Activity
Active isomer of medetomidine (Cat.No. 5160), a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Technical Data
  • M.Wt:
    236.74
  • Formula:
    C13H16N2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    145108-58-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist.
    Virtanen et al.
    Eur.J.Pharmacol., 1988;150:9
  2. Antinociceptive properties of intrathecal dexmedetomidine in rats.
    Fisher et al.
    Eur.J.Pharmacol., 1991;192:221
  3. Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects.
    Scheinin et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 1989;13:635
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine.
    Authors: McAlvin Et al.
    J Inflamm (Lond) 2015;56:3820
  2. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.
    Authors: Garrity Et al.
    Invest Ophthalmol Vis Sci 2015;38:73
  3. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.
    Authors: Yuki Et al.
    Anesth Analg 2011;112:830

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