Dexmedetomidine hydrochloride

Key Product Details

Product Description

Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α₂-adrenoceptor agonist (K_i values are 1.08 and 1750 nM for α₂- and α₁-adrenoceptors respectively). Displays greater selectivity over α₁-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Racemate also available.

Product Specifications for Dexmedetomidine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dexmedetomidine hydrochloride

The following data is based on the product molecular weight 236.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

• Fisher Antinociceptive properties of intrathecal dexmedetom. in rats. Eur.J.Pharmacol. 1991 PMID: 1674472
• Scheinin Medetomidine - a novel α₂-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 1989 PMID: 2571177
• Virtanen Characterization of the selectivity, specificity and potency of medetomidine as an α₂-adrenoceptor agonist. Eur.J.Pharmacol. 1988 PMID: 2900154

Product Documents for Dexmedetomidine hydrochloride