Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Biological ActivityDexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Racemate also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist.
Virtanen et al.
Antinociceptive properties of intrathecal dexmedetom. in rats.
Fisher et al.
Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects.
Scheinin et al.
Citations for Dexmedetomidine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:
7 Citations: Showing 1 - 7
Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines.
Authors: Uchida Et al.
Anticancer Res 2019;39:3519
Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation
Authors: Ma Et al.
Curr Biol 2019;29:3315
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
Corneal Anesthesia With Site 1 Sodium Channel Blockers and dexmedetom.
Authors: McAlvin Et al.
J Inflamm (Lond) 2015;56:3820
Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.
Authors: Garrity Et al.
Invest Ophthalmol Vis Sci 2015;38:73
Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
Authors: Gozzi Et al.
Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.
Authors: Yuki Et al.
Anesth Analg 2011;112:830
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