Dexmedetomidine hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:2749
Alternate Names:d-Medetomidine hydrochloride
Chemical Name:4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Product Details
Citations (5)
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Reviews
Biological Activity
Active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Racemate also available.

Technical Data
  • M.Wt:
    236.74
  • Formula:
    C13H16N2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    145108-58-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:

5 Citations: Showing 1 - 5
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  1. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  2. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine.
    Authors: McAlvin Et al.
    J Inflamm (Lond)  2015;56:3820
  3. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.
    Authors: Garrity Et al.
    Invest Ophthalmol Vis Sci  2015;38:73
  4. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
    Authors: Gozzi Et al.
    Neuropsychopharmacology  2013;38:2120
  5. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.
    Authors: Yuki Et al.
    Anesth Analg  2011;112:830

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