Medetomidine hydrochloride

Key Product Details

Product Description

Medetomidine hydrochloride is a potent, highly selective α₂-adrenoceptor agonist (K_i values are 1.08 and 1750 nM for α₂- and α₁-adrenoceptors respectively). Displays greater selectivity over α₁-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD₂ = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Active Isomer also available.

Product Specifications for Medetomidine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Medetomidine hydrochloride

The following data is based on the product molecular weight 236.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Virtanen Characterization of the selectivity, specificity and potency of medetomidine as an α₂-adrenoceptor agonist. Eur.J.Pharmacol. 1988 PMID: 2900154
• Scheinin Medetomidine - a novel α₂-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 1989 PMID: 2571177
• Savola Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 1986 PMID: 2880852

Product Documents for Medetomidine hydrochloride