Potent, highly selective α2
-adrenoceptor agonist (Ki
values are 1.08 and 1750 nM for α2
- and α1
-adrenoceptors respectively). Displays greater selectivity over α1
-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2
= 9.0). Active in vivo
; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors.
Savola et al.
Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects.
Scheinin et al.
Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist.
Virtanen et al.
The citations listed below are publications that use Tocris products. Selected citations for Medetomidine hydrochloride include:
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