Medetomidine hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:5160
Chemical Name:4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
Potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Active Isomer also available.

Technical Data
  • M.Wt:
    236.74
  • Formula:
    C13H16N2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    86347-15-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Medetomidine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Role of alpha2-adrenoceptors and glutamate mechanisms in the external urethral sphincter continence reflex in rats.
    Authors: Furuta Et al.
    J.Urol.  2009;181:1467
  2. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
    Authors: Moura Et al.
    Br J Pharmacol  2006;149:1049

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