DIDS

Catalog # Availability Size / Price Qty
4523/50
Cat.No. 4523 - DIDS | C16H8N2Na2O6S4 | CAS No. 67483-13-0
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Description: Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt

Purity: ≥95%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).

Technical Data

M.Wt:
498.48
Formula:
C16H8N2Na2O6S4
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in Potassium bicarbonate (0.1M)
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
67483-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for DIDS

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Blocks cellular swelling
By Anonymous on 02/06/2018
Species: Rat

Used at 250microM-500microM to block cellular swelling in the rat brain slice.


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