DIDS
Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
Purity: ≥95%
Biological Activity
DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids.
Riquelme and Parra et al.
Am.J.Obstet.Gynecol., 1999;180:469 -
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida et al.
Nucleic Acids Res., 2009;37:3367 -
New light on the "old" chloride channel blocker DIDS.
Wulff
ACS Chem.Biol., 2008;3:399 -
Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Zhang et al.
Mol.Pharmacol., 2012;81:689
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for DIDS
The citations listed below are publications that use Tocris products. Selected citations for DIDS include:
4 Citations: Showing 1 - 4
-
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
-
The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.
Authors: Roebber Et al.
J Neurosci 2019;39:6224
-
SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
BMB Rep 2014;289:23189
-
Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Biol Chem 2013;4:e969
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for DIDS
Average Rating: 5 (Based on 1 Review)
Have you used DIDS?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Used at 250microM-500microM to block cellular swelling in the rat brain slice.
