ClC-Ka chloride channel blocker (IC50
= 100 μ
M). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50
= 4.88 μ
M in rat DRG neurons). Inhibits RAD51 recombinase activity (KD
= 2 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids.
Riquelme and Parra et al.
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida et al.
Nucleic Acids Res., 2009;37:3367
New light on the "old" chloride channel blocker DIDS.
ACS Chem.Biol., 2008;3:399
Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Zhang et al.
The citations listed below are publications that use Tocris products. Selected citations for DIDS include:
Showing Results 1 - 2 of 2