Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
Biological ActivityDIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids.
Riquelme and Parra et al.
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida et al.
Nucleic Acids Res., 2009;37:3367
New light on the "old" chloride channel blocker DIDS.
ACS Chem.Biol., 2008;3:399
Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Zhang et al.
Citations for DIDS
The citations listed below are publications that use Tocris products. Selected citations for DIDS include:
4 Citations: Showing 1 - 4
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Authors: Rastogi Et al.
PLoS Pathog 2021;17:e1009712
The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.
Authors: Roebber Et al.
J Neurosci 2019;39:6224
SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
BMB Rep 2014;289:23189
Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Biol Chem 2013;4:e969
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Used at 250microM-500microM to block cellular swelling in the rat brain slice.