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DIDS

4523 4 Citations 1 Review Datasheet / COA / SDS
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4523/50
DIDS | CAS No. 67483-13-0 | Buffers, Chelators and Reagents
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Description: Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt

Purity: ≥95%

Product Details
Citations (4)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).

Technical Data

M.Wt:
498.48
Formula:
C16H8N2Na2O6S4
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in Potassium bicarbonate (0.1M)
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
67483-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DIDS

The citations listed below are publications that use Tocris products. Selected citations for DIDS include:

4 Citations: Showing 1 - 4

  1. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
    Authors: Rastogi Et al.
    PLoS Pathog  2021;17:e1009712
  2. The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.
    Authors: Roebber Et al.
    J Neurosci  2019;39:6224
  3. SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
    Authors: Cao Et al.
    BMB Rep  2014;289:23189
  4. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    J Biol Chem  2013;4:e969

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VersaClone cDNA Plasmids

Rat Vanilloid R1/TRPV1 (NP_114188) VersaClone cDNA

RDC1967

Reviews for DIDS

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Blocks cellular swelling
By Anonymous on 02/06/2018
Application: Species: Rat

Used at 250microM-500microM to block cellular swelling in the rat brain slice.

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