DIDS

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DIDS | CAS No. 67483-13-0 | Buffers, Chelators and Reagents
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Description: Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt

Purity: ≥95%

Product Details
Citations (10)
Supplemental Products
Reviews

Biological Activity

DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).

Technical Data

M.Wt:
498.48
Formula:
C16H8N2Na2O6S4
Solubility:
Soluble to 5 mM in Potassium bicarbonate (0.1M)
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
67483-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DIDS

The citations listed below are publications that use Tocris products. Selected citations for DIDS include:

10 Citations: Showing 1 - 10

  1. Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter.
    Authors: Matthew Et al.
    J Physiol  2021;599:3195-3220
  2. Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel.
    Authors: Xing-Zhen Et al.
    iScience  2021;24:103395
  3. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
    Authors: Rastogi Et al.
    PLoS Pathog  2021;17:e1009712
  4. Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression.
    Authors: Myung-Jin Et al.
    Cells  2020;9
  5. Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.
    Authors: Georg Et al.
    Cell Death Dis  2020;11:714
  6. Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255-257 and regulated by mTOR.
    Authors: Bernhard Et al.
    Glia  2019;67:2264-2278
  7. The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.
    Authors: Roebber Et al.
    J Neurosci  2019;39:6224
  8. TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
    Authors: Koichi Et al.
    Neuron  2019;104:960-971.e7
  9. SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
    Authors: Cao Et al.
    BMB Rep  2014;289:23189
  10. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    J Biol Chem  2013;4:e969

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