DIDS
Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
Purity: ≥95%
Biological Activity
ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids.
Riquelme and Parra et al.
Am.J.Obstet.Gynecol., 1999;180:469 -
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida et al.
Nucleic Acids Res., 2009;37:3367 -
New light on the "old" chloride channel blocker DIDS.
Wulff
ACS Chem.Biol., 2008;3:399 -
Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Zhang et al.
Mol.Pharmacol., 2012;81:689
Product Datasheets
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Citations for DIDS
The citations listed below are publications that use Tocris products. Selected citations for DIDS include:
2 Citations: Showing 1 - 2
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SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
BMB Rep 2014;289:23189
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Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Biol Chem 2013;4:e969
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Used at 250microM-500microM to block cellular swelling in the rat brain slice.
