DIDS

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4523
Chemical Name:4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).
Technical Data
  • M.Wt:
    498.48
  • Formula:
    C16H8N2Na2O6S4
  • Solubility:
    Soluble to 10 mM in DMSO and to 10 mM in Potassium bicarbonate (0.1M)
  • Purity:
    >95
  • Storage:
    Store at +4°C
  • CAS No:
    67483-13-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DIDS include:

2 Citations: Showing 1 - 2
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  1. SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
    Authors: Cao Et al.
    BMB Rep  2014;289:23189
  2. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    J Biol Chem  2013;4:e969

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Rat Vanilloid R1/TRPV1 (NP_114188) VersaClone cDNA

RDC1967
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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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