Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt
Biological ActivityClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).
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Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids.
Riquelme and Parra et al.
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Ishida et al.
Nucleic Acids Res., 2009;37:3367
New light on the "old" chloride channel blocker DIDS.
ACS Chem.Biol., 2008;3:399
Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Zhang et al.
Citations for DIDS
The citations listed below are publications that use Tocris products. Selected citations for DIDS include:
2 Citations: Showing 1 - 2
SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability.
Authors: Cao Et al.
BMB Rep 2014;289:23189
Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
J Biol Chem 2013;4:e969
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Average Rating: 5 (Based on 1 Review)
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Used at 250microM-500microM to block cellular swelling in the rat brain slice.