Chemical Name: 4,4'-(1-Triazene-1,3-diyl)bis[benzenecarboximidamide] bis(N-acetylglycinate)
Biological ActivityDiminazene aceturate is an ASIC blocker (IC50 values are 202, ~320, ~320 and 864 nM for ASIC1b, ASIC1a, ASIC3 and ASIC2a, respectively). Exhibits no activity in ENaC channels expressed in oocytes. Accelerates desensitization of ASIC currents in hippocampal neurons. Inhibits mesotrypsin (Ki = 3.6�0.3 μM). Displays in vitro and in vivo anti-inflammatory effects in mice. Antihyperalgesic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.
Lee et al.
Small molecule inhibitors of mesotrypsin from a structure-based docking screen.
Kayode et al.
PLoS One, 2017;12:e0176694
Diarylamidines: high potency inhibitors of acid-sensing ion channels.
Chen et al.
Molecular basis of inhibition of acid sensing ion channel 1A by diminazene.
Krauson et al.
PLoS One, 2018;13:e0196894
Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes.
Goru et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Diminazene aceturate
There are currently no reviews for this product. Be the first to review Diminazene aceturate and earn rewards!
Have you used Diminazene aceturate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image