receptor ligand and psychoactive plant compound (Ki
= 14.8 μ
M). Binding to σ1
inhibits voltage-gated Na+
channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A
receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki
= 4.0 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.
Fontanilla et al.
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter.
Cozzi et al.
J.Neural Transm., 2009;116:1591
The citations listed below are publications that use Tocris products. Selected citations for DMT include:
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