Catalog Number: 3428
Alternate Names: Dimethyltryptamine
Chemical Name: N,N-Dimethyl-1H-indole-3-ethanamine
Biological Activity
Endogenous σ1 receptor ligand and psychoactive plant compound (Ki = 14.8 μM). Binding to σ1 inhibits voltage-gated Na+ channels and is responsible for the behavioral effects of DMT. Also a 5-HT2A receptor agonist and inhibitor of 5-HT uptake at plasma membrane serotonin transporters (SERT) (Ki = 4.0 μM).
Technical Data
  • M.Wt:
    188.27
  • Formula:
    C12H16N2
  • Solubility:
    Soluble to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    61-50-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.
    Fontanilla et al.
    Science, 2009;323:934
  2. Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transportere and the vesicle monoamine transporter.
    Cozzi et al.
    J.Neural Transm., 2009;116:1591
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DMT include:

1 Citations: Showing 1 - 1

  1. A temporal shift in the circuits mediating retrieval of fear memory.
    Authors: Do-Monte Et al.
    BMC Cancer 2015;519:460

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