DNAM-1/CD226 Antibody (S03-4I5)

Novus Biologicals | Catalog # NBP3-20033

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S03-4I5 expressed in HEK293
View all DNAM-1/CD226 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human DNAM-1/CD226 (Uniprot # Q15762)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DNAM-1/CD226 Antibody (S03-4I5)

Western Blot: DNAM-1/CD226 Antibody (S03-4I5) [NBP3-20033]

Western Blot: DNAM-1/CD226 Antibody (S03-4I5) [NBP3-20033]

Western Blot: DNAM-1/CD226 Antibody (S03-4I5) [NBP3-20033] - Western blot detection of DNAM-1/CD226 in Jurkat cell lysates using NBP3-20033 (1:500 diluted). Predicted band size: 39kDa. Observed band size: 60-80kDa.

Applications for DNAM-1/CD226 Antibody (S03-4I5)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DNAM-1/CD226

CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.

Long Name

DNAX Accessory Molecule 1

Alternate Names

CD226, DNAM1, PTA1, TLiSA1

Gene Symbol

CD226

Additional DNAM-1/CD226 Products

Product Documents for DNAM-1/CD226 Antibody (S03-4I5)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for DNAM-1/CD226 Antibody (S03-4I5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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