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DPPE fumarate

Catalog #: 0743
1 Citation Datasheet / COA / SDS

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DPPE fumarate | CAS No. 1185241-83-1 | Histaminergic-Related Compounds
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Description: Inhibitor of histamine binding at the intracellular binding site

Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine fumarate

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.

Technical Data

M.Wt:
399.49
Formula:
C19H25NO.C4H4O4
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
1185241-83-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Histamine as an intracellular messenger.
    Brandes et al.
    Biochem.Pharmacol., 1990;40:1677
  3. A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes.
    Brandes and Hermonat
    Biochem.Biophys.Res.Commun., 1984;123:724
  4. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
    Sturman et al.
    Agents Actions, 1994;41:C68
  5. Molecular characterization of the microsomal tamox. binding site.
    Kedjouar et al.
    J.Biol.Chem., 2004;279:34048

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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Citation for DPPE fumarate

The citations listed below are publications that use Tocris products. Selected citations for DPPE fumarate include:

1 Citation: Showing 1 - 1

  1. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
    Authors: Dolma Et al.
    Cancer Cell  2016;29:859

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