Catalog Number: 0743
Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine fumarate
Biological Activity
Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor.�Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular characterization of the microsomal tamoxifen binding site.
    Kedjouar et al.
    J.Biol.Chem., 2004;279:34048
  2. Histamine as an intracellular messenger.
    Brandes et al.
    Biochem.Pharmacol., 1990;40:1677
  3. A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes.
    Brandes and Hermonat
    Biochem.Biophys.Res.Commun., 1984;123:724
  4. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
    Sturman et al.
    Agents Actions, 1994;41:C68

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