Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50
values are 0.20 and 0.24 μ
M for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo
and in vitro
. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.
Nakajima et al.
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors.
Jagtap and Szabo
Nat.Rev.Drug Discov., 2005;4:421