receptor antagonist. Also exhibits affinity for 5-HT, α
-adrenergic and histamine receptors,and hERG channels. Antipsychotic and antiemetic.
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All Tocris products are intended for laboratory research use only.
Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency.
Peroutka and Synder
A two-state homology model of the hERG K+ channel: application to ligand binding.
Rajamani et al.