Catalog Number: 5858
Chemical Name: 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
Biological Activity
D2 receptor antagonist. Also exhibits affinity for 5-HT, α-adrenergic and histamine receptors,and hERG channels. Antipsychotic and antiemetic.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency.
    Peroutka and Synder
    Am.J.Psychiatry, 1980;137:1518
  2. A two-state homology model of the hERG K+ channel: application to ligand binding.
    Rajamani et al.
    Bioorg.Med.Chem.Lett., 2005;15:1737
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