Catalog Number: 2958
Chemical Name: N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
Biological Activity
Adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.
Technical Data
  • M.Wt:
    313.06
  • Formula:
    C11H15BrClN.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    40616-75-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats.
    Jaim-Etcheverry and Zieher
    Brain Res., 1980;188:513
  2. Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration.
    Kawamura et al.
    Biomed.Pharmacother., 2005;59:S203
  3. Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces dopamine release potential in the nucleus accumbens shell in conscious rats.
    Haidkind et al.
    Neurosci.Letts., 2002;332:79
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DSP-4 include:

2 Citations: Showing 1 - 2
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  1. Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain.
    Authors: Li Et al.
    Toxins (Basel) 2015;7:2422
  2. Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex.
    Authors: Coura Et al.
    FASEB J 2013;27:4343

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