DYRK2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-76560

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all DYRK2 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DYRK2. The immunogen is located within amino acids 520 - 570 of DYRK2. Amino Acid Squence: LRRRLPKPPTGEKTSCKR

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (89%), Mouse (89%)

Specificity

Two isoforms of DYRK2 are known to exist; this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DYRK2 Antibody - BSA Free

DYRK2 Antibody - BSA Free

Western Blot: DYRK2 Antibody - BSA Free [NBP1-76560] -

Western Blot: DYRK2 Antibody - BSA Free [NBP1-76560] - Western blot analysis of DYRK2 in 293 cell lysate with DYRK2 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: DYRK2 Antibody - BSA Free [NBP1-76560]

Immunocytochemistry/ Immunofluorescence: DYRK2 Antibody - BSA Free [NBP1-76560]

Immunocytochemistry/Immunofluorescence: DYRK2 Antibody [NBP1-76560] - Immunofluorescence of DYRK2 in 293 cells with DYRK2 antibody at 20 ug/mL.
DYRK2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: DYRK2 Antibody - BSA Free [NBP1-76560] -

Immunocytochemistry/ Immunofluorescence: DYRK2 Antibody - BSA Free [NBP1-76560] - Immunocytochemistry of DYRK2 in 293 cells with DYRK2 antibody at 10 ug/mL.

Applications for DYRK2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10-20 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DYRK2

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 2

Alternate Names

dual specificity tyrosine-phosphorylation-regulated kinase 2, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2, EC 2.7.12, EC 2.7.12.1, FLJ21217, FLJ21365

Gene Symbol

DYRK2

UniProt

NP_006473 (Human)

Additional DYRK2 Products

Product Documents for DYRK2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for DYRK2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Intracellular Kinases

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Protocols

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FAQs

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