EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-76710

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all EDA2R/TNFRSF27/XEDAR Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against recombinant human XEDAR.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 26352300).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

Western Blot: EDA2R/TNFRSF27/XEDAR AntibodyBSA Free [NBP1-76710]

Western Blot: EDA2R/TNFRSF27/XEDAR AntibodyBSA Free [NBP1-76710]

Western Blot: EDA2R/TNFRSF27/XEDAR Antibody [NBP1-76710] - 293 cell lysate with EDA2R antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

Immunohistochemistry: EDA2R/TNFRSF27/XEDAR Antibody - BSA Free [NBP1-76710] -

Immunohistochemistry: EDA2R/TNFRSF27/XEDAR Antibody - BSA Free [NBP1-76710] - Immunohistochemistry of EDA2R/TNFRSF27/XEDAR in human skin tissue with EDA2R/TNFRSF27/XEDAR antibody at 10 ug/mL.

Applications for EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

10 ug/ml

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: EDA2R/TNFRSF27/XEDAR

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.

Long Name

Ectodysplasin A2 Receptor

Alternate Names

EDAA2R, TNFRSF27, XEDAR

Gene Symbol

EDA2R

UniProt

AAQ89953 (Human)

Additional EDA2R/TNFRSF27/XEDAR Products

Product Documents for EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

NFkB Pathway
p53 Pathway

Citations for EDA2R/TNFRSF27/XEDAR Antibody - BSA Free

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Protocols

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