Catalog Number: 0792
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride
Biological Activity
Potent, highly selective α2 adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A, α2B, α2C, I1, and I2 receptors respectively). Promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3 receptor) in vitro and in vivo.
Technical Data
  • M.Wt:
    252.74
  • Formula:
    C13H16N2O.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    89197-00-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. α-Adrenoceptor reagents 2. Effects of modification of the 1,4-benzodioxan ring system on α-adrenoceptor activity.
    Chapleo et al.
    J.Med.Chem., 1984;27:570
  2. 'Seeing through a glass darkly': casting light on imidazoline 'I' sites.
    Eglen et al.
    TiPS, 1998;19:381
  3. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse.
    Mayer and Taberner
    Eur.J.Pharmacol., 2002;454:95
  4. Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
    Olmos et al.
    Eur.J.Pharmacol., 1994;262:41

Have you used Efaroxan hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Feedback

Customer Information