Catalog Number: 0873
Chemical Name: (S)-Ethylisothiourea hydrobromide
Biological Activity
Potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent and selective inhibition of human nitric oxide synthase.
    Garvey et al.
    J.Biol.Chem., 1994;269:26669
  2. Novel potent and selective inhibitors of inducible nitric oxide synthase.
    Nakane et al.
    Mol.Pharmacol., 1995;47:831
  3. Effects of S-ethylisothiourea, a potent inhibitor of nitirc oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock.
    Squadrito et al.
    Br.J.Pharmacol., 1996;119:23

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