Catalog Number: 4646
Alternate Names: GF 120918
Chemical Name: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride
Biological Activity
P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active.
Technical Data
  • M.Wt:
    600.1
  • Formula:
    C34H33N3O5.HCl
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    143851-98-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.
    Hyafil et al.
    Cancer Res., 1993;53:4595
  2. The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line.
    Myer et al.
    Oncol Rep., 1999;6:217
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Elacridar hydrochloride include:

1 Citations: Showing 1 - 1

  1. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics.
    Authors: Jablonski Et al.
    Ann Clin Transl Neurol 2014;1:996

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