Elacridar hydrochloride

Tocris Bioscience | Catalog # 4646

P-gp and BCRP inhibitor
Tocris Bioscience

Key Product Details

Description

P-gp and BCRP inhibitor

Alternative Names

GF 120918
View all Multidrug Transporter Inhibitors »

Product Description

Elacridar hydrochloride is a P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) inhibitor. Elacridar hydrochloride blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for Elacridar hydrochloride

Molecular Weight

600.10

Formula

C34H33N3O5.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

CAS Number

143851-98-3

PubChem ID

170320

InChI Key

IQOJZZHRYSSFJM-UHFFFAOYSA-N

SMILES

O=C1C3=C(C(C(NC4=CC=C(CCN5CC(C=C(OC)C(OC)=C6)=C6CC5)C=C4)=O)=CC=C3)NC2=C1C=CC=C2OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12 20

Preparing Stock Solutions for Elacridar hydrochloride

The following data is based on the product molecular weight 600.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.33 mL 41.66 mL 83.32 mL
1 mM 1.67 mL 8.33 mL 16.66 mL
2 mM 0.83 mL 4.17 mL 8.33 mL
10 mM 0.17 mL 0.83 mL 1.67 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Product Documents for Elacridar hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Elacridar hydrochloride

For research use only

Citations for Elacridar hydrochloride

Customer Reviews for Elacridar hydrochloride (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Elacridar hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card
Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • 1uM of elacridar is used to block the p glycoprotein
    Name: Shashirekha Shamamandri Markandaiah
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Endothelial cell, Astrocytes
    Verified Customer | Posted 10/29/2018
    Elacridar is used as P glycoprotein transporter blocker to enhance drug penetration in iPsc derived endothelial cell co cultured with ALS astrocytes.

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All