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Elacridar hydrochloride

4646 3 Citations 1 Review Datasheet / COA / SDS
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Elacridar hydrochloride | CAS No. 143851-98-3 | Multidrug Transporter Inhibitors
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Description: P-gp and BCRP inhibitor
Alternative Names: GF 120918

Chemical Name: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Elacridar hydrochloride is a P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) inhibitor. Elacridar hydrochloride blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Orally active.

Technical Data

M.Wt:
600.1
Formula:
C34H33N3O5.HCl
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
143851-98-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.

Product Datasheets

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Citations for Elacridar hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Elacridar hydrochloride include:

3 Citations: Showing 1 - 3

  1. Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.
    Authors: Lahmann Et al.
    PLoS One  2015;10:e0134476
  2. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.
    Authors: Ramesh Et al.
    J Exp Med  2014;211:89
  3. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics.
    Authors: Jablonski Et al.
    Ann Clin Transl Neurol  2014;1:996

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1uM of elacridar is used to block the p glycoprotein
By Shashirekha Shamamandri Markandaiah on 10/29/2018
Application: Species: Mouse

Elacridar is used as P glycoprotein transporter blocker to enhance drug penetration in iPsc derived endothelial cell co cultured with ALS astrocytes.

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