Catalog Number: 4209
Chemical Name: 2-Ethyl-5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine oxalate
Biological Activity
Selective 5-HT6 agonist (with a Ki value of 16 nM at human 5-HT6 receptors). Exhibits potency comparable to serotonin for the activation of adenylate cyclase. Displays antidepressant-like effects.
Technical Data
  • M.Wt:
    336.38
  • Formula:
    C15H22N2O.C2H2O4
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    263744-72-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors.
    Glennon et al.
    J.Med.Chem., 2000;43:1011
  2. Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation.
    Svenningsson et al.
    J.Neurosci., 2007;27:4201

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