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Epithelial to Mesenchymal Transition Products
To induce and evaluate EMT, the biological process implicated in CSC generation and metastasis.
Epithelial to mesenchymal transition (EMT) is critical for normal embryonic development, and aberrantly reactivated EMT mechanisms in adults contribute to pathological states such as metastasis. Growing evidence indicates that EMT mechanisms contribute to cancer stem cell (CSC) generation, suggesting that therapeutic targeting of EMT may restrict CSCs and inhibit migratory behavior associated with metastasis.