Microtubule stabilization agent that promotes tubulin polymerization and induces G2
-M cell cycle arrest (EC50
= 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro
, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50
values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo
Soluble to 10 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity.
Altmann et al.
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
O'Reilly et al.
Cancer Chemother.Pharmacol., 2008;62:1045
Altered TUBB3 expression contributes to the epothilone response of mitotic cells.
Narvi et al.