ER 27319 maleate
Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Biological ActivityER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases.
Luskova and Draber
ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk.
Moriya et al.
Citations for ER 27319 maleate
The citations listed below are publications that use Tocris products. Selected citations for ER 27319 maleate include:
2 Citations: Showing 1 - 2
Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells.
Authors: Rycaj Et al.
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
Authors: Ng Et al.
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In-vitro luciferase assay