Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of Fcε
RI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α
= 10 μ
M) and other related signaling events.
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Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases.
Luskova and Draber
ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk.
Moriya et al.
The citations listed below are publications that use Tocris products. Selected citations for ER 27319 maleate include:
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