Catalog Number: 2471
Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Biological Activity
Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.
Technical Data
  • M.Wt:
    396.17
  • Formula:
    C18H20N2O.C4H4O4
  • Solubility:
    Soluble to 75 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1204480-26-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases.
    Luskova and Draber
    Curr.Pharm.Des., 2004;10:1727
  2. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk.
    Moriya et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:12539
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ER 27319 maleate include:

1 Citations: Showing 1 - 1

  1. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
    Authors: Ng Et al.
    Immunity 2008;29:807

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