ER 27319 maleate

Tocris Bioscience | Catalog # 2471

Selective Syk kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Selective Syk kinase inhibitor
View all Syk Kinase Inhibitors »

Product Description

ER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.

Product Specifications for ER 27319 maleate

Molecular Weight

396.17

Formula

C18H20N2O.C4H4O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate

CAS Number

1204480-26-1

PubChem ID

56972172

InChI Key

WVUQPGFRFBVJKH-BTJKTKAUSA-N

SMILES

OC(=O)\C=C/C(O)=O.CC1=C(C)C2=C(C=C1)C(=O)C1=CC=CC=C1N2CCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.71 75
DMSO 39.62 100

Preparing Stock Solutions for ER 27319 maleate

The following data is based on the product molecular weight 396.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.24 mL
5 mM 0.50 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for ER 27319 maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ER 27319 maleate

For research use only

Citations for ER 27319 maleate

Customer Reviews for ER 27319 maleate (1)

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  • Potential candidate to control for expression of the protein of interest
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HeLa
    Verified Customer | Posted 01/04/2018
    In-vitro luciferase assay

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