ER 27319 maleate

Catalog # Availability Size / Price Qty
2471/10
2471/50
ER 27319 maleate | CAS No. 1204480-26-1 | Syk Kinase Inhibitors
1 Image
Description: Selective Syk kinase inhibitor

Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.

Technical Data

M.Wt:
396.17
Formula:
C18H20N2O.C4H4O4
Solubility:
Soluble to 75 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
1204480-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases.
    Luskova and Draber
    Curr.Pharm.Des., 2004;10:1727
  2. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk.
    Moriya et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:12539

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for ER 27319 maleate

The citations listed below are publications that use Tocris products. Selected citations for ER 27319 maleate include:

2 Citations: Showing 1 - 2

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ER 27319 maleate

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used ER 27319 maleate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Potential candidate to control for expression of the protein of interest
By Anonymous on 01/04/2018
Species: Human

In-vitro luciferase assay


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.