Catalog Number: 0438
Chemical Name: 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM).
Technical Data
  • M.Wt:
    325.8
  • Formula:
    C14H19N5O2.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    35838-58-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
    Nicholson et al.
    TiPS, 1991;12:19
  2. 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase.
    Chesin et al.
    Biochem.Pharmacol., 1972;21:2443
  3. Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction.
    Rhoads
    Biochem.Pharmacol., 1982;31:665

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