Extracellular Matrix Molecules

In addition to pre-coated microplates, R&D Systems offers a range of recombinant ECM molecules which can be applied to cell culture plates to promote cell adhesion.

Many proteins of the ECM interact with cells via cell surface integrin family receptors. The resulting focal contacts are important for the maintenance of tissue architecture and for supporting a variety of cellular processes. ECM molecule/integrin binding may initiate a complex network of signal transduction cascades that, depending on the context, play an important role in cell spreading, migration, proliferation, and differentiation during embryogenesis, wound healing, and tumor development.


A heparan sulfate proteoglycan, Agrin is a component of the synaptic basal lamina.


Also known as Aggrecan-1, chondroitin sulfate proteoglycan, and large aggregating proteoglycan, Aggrecan is the key component of the cartilage extracellular matrix.


Type-I collagen is the major structural component of extracellular matrices found in connective tissue and internal organs. It is most prevalent in the dermis, tendons, and bone.


Decorin is a small secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin has been implicated in matrix assembly.


One of the primary cell adhesion molecules, Fibronectin plays an important role in normal morphogenesis, including cell adhesion, migration, differentiation, and specific gene expression.


This highly purified preparation of mouse Laminin-1 increases cell adhesion, migration, growth, and differentiation.


Matrix Extracellular Phosphoglycoprotein (MEPE), also known as OF45 in mouse and rat, is primarily expressed in bone and dentin.


Also know as entactin, Nidogen-1 is a secreted, monomeric glycoprotein that serves as a major linking component of basement membranes.


Also known as Spondin-1 and VSGP, F-Spondin is a secreted, heparan-binding extracellular matrix glycoprotein.


R-Spondins (Roof plate-specific Spondin) are expressed in early development at the roof plate boundary and are thought to contribute to dorsal neural tube development.

Tenascins are high molecular weight extracellular matrix glycoproteins that have a complex spatial and temporal pattern of expression during embryogenesis, wound healing and neoplastic processes.


Testicans are proteoglycans which are highly expressed in brain tissue.


A larger glycoprotein involved in a number of biological functions including cell adhesion, cell spreading migration, proliferation, extracellular anchoring, fibrinolysis, hemostasis, and complement immune defense.

R&D Systems also offers traditional synthetic products to promote cell adhesion.


A highly positively charged amino acid chain, commonly used as a coating agent to promote cell adhesion in culture (Catalog # 3438-100-01).

Culture Microplates

R&D Systems offers packs of high-binding, flat-bottom polystyrene 96-well microplates. Each microplate consists of twelve removable strips of 8 wells and are available in both clear (Catalog # DY990) and black (Catalog # DY991).

Extracellular Matrix Pre-coated Plates

96-well microplates pre-coated with fibronectin or vitronectin.

Basement Membrane Extracts

An alternative approach to promote cell adhesion.