Chemical Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Biological ActivityFenofibrate is a PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofi. treatment.
Mandard et al.
PPARα agonist fenofi. improves diabetic nephropathy in db/db mice.
Park et al.
Kidney Int., 2006;69:1511
Pleiotropic actions of fenofi. on the heart.
Balakumar et al.
Citations for Fenofibrate
The citations listed below are publications that use Tocris products. Selected citations for Fenofibrate include:
5 Citations: Showing 1 - 5
Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency.
Authors: Lee Et al.
J Clin Med 2018;7
Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
Authors: Helmy Et al.
PLoS One 2015;10:e0142303
Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
Authors: Nagiec Et al.
J Pharmacol Exp Ther 2015;10:e0120295
Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
Authors: Redlich Et al.
PLoS One 2014;11:108
5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Invest Ophthalmol Vis Sci 2011;339:886
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