FGFR3 (fibroblast growth factor receptor 3), also known as CEK2 and CD333, is a transmembrane receptor tyrosine kinase that plays a role in skeletal development and tumorigenesis. Alternative splicing generates beta isoforms of the receptor which lack the first Ig-like domain as well as IIIb isoforms that have a substitution in the third Ig-like domain. FGFR3 (IIIb) triggers cell proliferation in response to FGF acidic and FGF-9, while FGFR3 (IIIc) shows a wider selectivity that includes FGF acidic, FGF basic/FGF2, FGF-4, -8, -9, -17, -18, -19, and -20. FGF mediated activation of FGFR3 is dependent on the presence of heparan sulfate proteoglycans. FGFR3 functions as a negative regulator of endochondral bone growth, and FGFR3 mutations are associated with chondrodysplasia in humans. The development of many cancers is associated with mutations or dysregulation of FGFR3.
FGFR3 Antibody (046) [Alexa Fluor™ Plus 488]
Novus Biologicals | Catalog # NBP2-90393AFP488
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Clonality
Host
Isotype
Applications for FGFR3 Antibody (046) [Alexa Fluor™ Plus 488]
ELISA
Sandwich ELISA Detection
Formulation, Preparation, and Storage
Purification
Formulation
Preservative
Concentration
Shipping
Stability & Storage
Background: FGFR3
Long Name
Alternate Names
Gene Symbol
Additional FGFR3 Products
Product Documents for FGFR3 Antibody (046) [Alexa Fluor™ Plus 488]
Certificate of Analysis
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Product Specific Notices for FGFR3 Antibody (046) [Alexa Fluor™ Plus 488]
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- View all Protocols, Troubleshooting, Illustrated assays and Webinars
