Naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.
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All Tocris products are intended for laboratory research use only.
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Lu et al.
Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.
Adhami et al.
Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells.
Haddad et al.
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.
Maher et al.
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.
Lee et al.
The citations listed below are publications that use Tocris products. Selected citations for Fisetin include:
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