FKBP52/FKBP4 Antibody

Name: FKBP52/FKBP4 Antibody
Brand: Novus Biologicals
SKU: NB100-68237
Price: 459 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-68237

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 400 and 440 human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FKBP52/FKBP4 Antibody

Western Blot: FKBP52/FKBP4 Antibody [NB100-68237]

Western Blot: FKBP52/FKBP4 Antibody [NB100-68237] - Western Blot and Immunoprecipitation: FKBP4/FKBP52 Antibody NB100-68237 -Detection of Human FKBP4/FKBP52 on HeLa whole cell lysate (5, 15, and 50 microgram) and 293T cell lysate (50 microgram) using NB100-68237. FKBP4/FKBP52 was also immunoprecipitated by rabbit anti-FKBP4/FKBP52 antibody NB100-68236 and NB100-68238.

Immunohistochemistry: FKBP52/FKBP4 Antibody [NB100-68237]

Immunohistochemistry: FKBP52/FKBP4 Antibody [NB100-68237] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-FKBP4/FKBP52 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB

Applications for FKBP52/FKBP4 Antibody

Application

Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Application Notes

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: FKBP52

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.

Long Name

52 kDa FK506 Binding Protein

Alternate Names

FKBP4, FKBP59, HBI, Hsp56

Entrez Gene IDs

2288 (Human)

Gene Symbol

FKBP4

UniProt

NP_002005.1 (Human)

Additional FKBP52 Products

Product Documents for FKBP52/FKBP4 Antibody

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Certificate of Analysis

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Product Specific Notices for FKBP52/FKBP4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Phosphatases and Regulators

Citations for FKBP52/FKBP4 Antibody

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