FKBP52/FKBP4 Antibody

Novus Biologicals | Catalog # NBP1-18845

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all FKBP52 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-DHPTDTEMKEEQKSN corresponding to C-Terminus according to NP_002005.1.

Epitope

C Terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Theoretical MW

52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FKBP52/FKBP4 Antibody

Western Blot: FKBP52/FKBP4 Antibody [NBP1-18845]

Western Blot: FKBP52/FKBP4 Antibody [NBP1-18845]

Western Blot: FKBP52/FKBP4 Antibody [NBP1-18845] - (0.01ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.
Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody [NBP1-18845]

Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody [NBP1-18845]

Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody [NBP1-18845] - (3.75ug/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody [NBP1-18845]

Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody [NBP1-18845]

Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody [NBP1-18845] - (3.75ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for FKBP52/FKBP4 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

3.75 ug/ml

Peptide ELISA

Detection limit 1:8000

Western Blot

0.01-0.03 ug/ml
Application Notes
Western blot: Approx 52kDa band observed in Human Placenta lysates (calculated MW of 51.8kDa according to NP_002005.1). Primary incubation was 1 hour.
IHC: Paraffin embedded Human Kidney and Brain (Cerebellum).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: FKBP52

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq]

Long Name

52 kDa FK506 Binding Protein

Alternate Names

FKBP4, FKBP59, HBI, Hsp56

Entrez Gene IDs

2288 (Human)

Gene Symbol

FKBP4

UniProt

Q02790

Additional FKBP52 Products

Product Documents for FKBP52/FKBP4 Antibody

Certificate of Analysis

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Product Specific Notices for FKBP52/FKBP4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Phosphatases and Regulators

Citations for FKBP52/FKBP4 Antibody

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Protocols

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