Catalog Number: 0522
Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Biological Activity
Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in ethanol and to 50 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy.
    Eichler et al.
    J.Neurochem., 1994;62:2148
  2. Ca+ and Na+ channels involved in neuronal cell death - protection by flunarizine.
    Pauwels et al.
    Life.Sci., 1991;48:1881
  3. Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage.
    Urenjak and Obrenovitch
    Pharmacol.Rev., 1996;48:21
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