Catalog Number: 1769
Chemical Name: 2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid
Biological Activity
Potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug.
    Glenn et al.
    Agents Actions, 1973;3:210
  2. The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
    Hoferova et al.
    Cancer Invest., 2002;20:490
  3. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
    Gierse et al.
    Biochem.J., 1995;305:479
  4. Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.
    Zemskova et al.
    Biochem.Pharmacol., 2006;72:1257
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