Chemical Name: 2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid
Biological ActivityFlurbiprofen is a potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase.
Zemskova et al.
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
Hoferova et al.
Cancer Invest., 2002;20:490
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
Gierse et al.
The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug.
Glenn et al.
Agents Actions, 1973;3:210
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