Flutax 1

Catalog # Availability Size / Price Qty
2226/1
Flutax 1 | CAS No. 191930-58-2 | Organelle and Cell Structure Stains
1 Image
Description: Fluorescent taxol derivative; binds microtubules

Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.

Flutax 1-labeled HeLa Cells

Flutax

Application of Flutax 1: Flutax 1 was diluted in HBSS and applied to live HeLa cells at a concentration of 2 �M. HeLa cells were incubated for 1 hour at 37�C. After incubation was complete, Flutax 1 was washed off, and fresh HBSS was applied to the cells. Cells were not fixed because Flutax 1 staining is not retained at all after fixation (photobleach). Staining can be done only on Live cells. Flutax 1 staining in live cells diminishes very rapidly when exposed to light, so the cells should be exposed to light as little as possible to retain good fluorescent signal.

Technical Data

M.Wt:
1283.3
Formula:
C71H66N2O21
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
191930-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Fluorescent taxoids as probes of the microtubule cytoskeleton.
    Evangelio et al.
    Cell Motil.Cytoskel., 1998;39:73
  2. Molecular recognition of Tax. by microtubules. Kinetics and thermodynamics of binding of fluorescent Tax. derivatives to an exposed site.
    Diaz et al.
    J.Biol.Chem., 2000;275:26265
  3. Fast kinetics of Tax. binding to microtubules.
    Diaz et al.
    J.Biol.Chem., 2003;278:8407

Product Datasheets

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Citations for Flutax 1

The citations listed below are publications that use Tocris products. Selected citations for Flutax 1 include:

2 Citations: Showing 1 - 2

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