Catalog Number: 2226
Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[
Biological Activity
A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.
Technical Data
  • M.Wt:
    1283.3
  • Formula:
    C71H66N2O21
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    191930-58-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site.
    Diaz et al.
    J.Biol.Chem., 2000;275:26265
  2. Fast kinetics of taxol binding to microtubules.
    Diaz et al.
    J.Biol.Chem., 2003;278:8407
  3. Fluorescent taxoids as probes of the microtubule cytoskeleton.
    Evangelio et al.
    Cell Motil.Cytoskel., 1998;39:73
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Flutax 1 include:

1 Citations: Showing 1 - 1

  1. Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.
    Authors: Kaittanis Et al.
    Nat Commun 2014;5:3384

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