Flutax 1

Catalog # Availability Size / Price Qty
2226/1
Cat.No. 2226 - Flutax 1 | C71H66N2O21 | CAS No. 191930-58-2
1 Image
Description: Fluorescent taxol derivative; binds microtubules

Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-yl ester N-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.

Technical Data

M.Wt:
1283.3
Formula:
C71H66N2O21
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
191930-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site.
    Diaz et al.
    J.Biol.Chem., 2000;275:26265
  2. Fast kinetics of taxol binding to microtubules.
    Diaz et al.
    J.Biol.Chem., 2003;278:8407
  3. Fluorescent taxoids as probes of the microtubule cytoskeleton.
    Evangelio et al.
    Cell Motil.Cytoskel., 1998;39:73

Product Datasheets

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Citations for Flutax 1

The citations listed below are publications that use Tocris products. Selected citations for Flutax 1 include:

2 Citations: Showing 1 - 2

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