Follistatin Antibody (FST/4281) - Azide and BSA Free

Novus Biologicals | Catalog # NBP3-08813

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin, ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # FST/4281

Format

Azide and BSA Free
View all Follistatin Primary Antibodies »

Product Specifications

Immunogen

Raised to human Follistatin (Fst) 288 and recognizes both human Fst 288 and 315 (Uniprot: P19883)

Localization

Secreted.

Specificity

Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. FST/4281 is a clone raised against recombinant Fst 288, and is used in combination, commonly as the capture, with antibody FST/4282 in a two site ELISA for the detection of Follistatin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

37 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-07491).

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C.

Scientific Data Images for Follistatin Antibody (FST/4281) - Azide and BSA Free

Immunohistochemistry-Paraffin: Follistatin Antibody (FST/4281) - Azide and BSA Free [NBP3-08813]

Immunohistochemistry-Paraffin: Follistatin Antibody (FST/4281) - Azide and BSA Free [NBP3-08813]

Immunohistochemistry-Paraffin: Follistatin Antibody (FST/4281) - Azide and BSA Free [NBP3-08813] - Formalin-fixed, paraffin-embedded human testis stained with Follistatin Mouse Monoclonal Antibody (FST/4281).

Applications for Follistatin Antibody (FST/4281) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
ELISA: Use in combination with clone FST/4282 for two-site ELISA

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Follistatin

FST, also known as Follistatin, has a 344 amino acid long isoform that is 38 kDa and a short 317 amino acid that is 35 kDa, functions as an activin antagonist binding directly to it and inhibits the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). Studies of this protein are being performed in relation to polycystic ovary syndrome, pituitary adenoma, insulin resistance, Down syndrome, plasmacytoma, lymphocytic leukemia, pituitary tumor infertility, endometrial carcinoma, teratocarcinoma, azoospermia, meningitis, hepatocellular carcinoma, ovarian carcinoma, liver disease, endometriosis, prostate carcinoma, prostatitis, ovarian cancer, and adenoma. This protein has been also shown to have interactions with ANG, DIP2A, BMP4, FN1, and TXN in signal transduction activin A signaling regulation and TGF-beta signaling pathways.

Alternate Names

FS, FST

Gene Symbol

FST

Additional Follistatin Products

Product Documents for Follistatin Antibody (FST/4281) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for Follistatin Antibody (FST/4281) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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