FosB/G0S3 Antibody (269928) [PE]

Name: FosB/G0S3 Antibody (269928) [PE]
Brand: Novus Biologicals
SKU: FAB2214P
Price: 529 USD
Availability: InStock

Novus Biologicals | Catalog # FAB2214P

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG_2B Clone # 269928

View all FosB/G0S3 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human FosB
Met1-Leu338
Accession # P53539

Specificity

Detects human FosB in Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for FosB/G0S3 Antibody (269928) [PE]

Application

Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: FosB/G0S3

Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Long Name

FBJ Murine Osteosarcoma Viral Oncogene Homolog B

Alternate Names

G0S3

Gene Symbol

FOSB

Additional FosB/G0S3 Products

Product Documents for FosB/G0S3 Antibody (269928) [PE]

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Certificate of Analysis

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Product Specific Notices for FosB/G0S3 Antibody (269928) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.