Chemical Name: 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid
Biological ActivitySelective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals.
Yamamoto et al.
The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site.
Kanno et al.
J.Lipid Res., 2006;47:1146
The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
Tanaka and Nishizaki
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for FR 236924
There are currently no reviews for this product. Be the first to review FR 236924 and earn rewards!
Have you used FR 236924?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image