FR 236924
Chemical Name: 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid
Purity: ≥99%
Biological Activity
Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A syndecan-4 binding peptide derived from laminin 5 uses a novel PKCepsilon pathway to induce cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells.
Filla M, Clark R, Peters D
Exp Cell Res, 2014;327(2):171-82. -
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals.
Yamamoto et al.
Neuroscience, 2005;130:207 -
The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site.
Kanno et al.
J.Lipid Res., 2006;47:1146 -
The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
Tanaka and Nishizaki
Bioorg.Med.Chem.Letts., 2003;13:1037
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