activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α
7 nicotinic receptors on glutamatergic terminals in vitro
and enhances cognition in vivo
. Brain penetrant.
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The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals.
Yamamoto et al.
The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site.
Kanno et al.
J.Lipid Res., 2006;47:1146
The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
Tanaka and Nishizaki