FRATide
Description: GSK-3 inhibitor
Biological Activity
Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalyzed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B.Technical Data
M.Wt:
4534.11
Formula:
C192H327N67O60
Sequence:
SQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQ
Storage:
Desiccate at -20°C
CAS No:
251087-38-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The structure of phosphorylated GSK-3β complexed with peptide, FRATtide, that inhibits α-catenin phosphorylation.
Bax et al.
Structure, 2001;9:1143 -
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and α-catenin
Thomas et al.
FEBS Lett., 1999;458:247
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