Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

DyLight 350 (Excitation = 353 nm, Emission = 432 nm)

Antibody Source

Polyclonal Goat IgG
View all Frizzled-2 Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-2
Gln29-Leu168
Accession # Q9JIP6

Specificity

Detects mouse Frizzled-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant mouse (rm) Frizzled-1 is observed and less than 5% cross-reactivity with rmFrizzled-4, recombinant human Frizzled-5, rmFrizzled-6, and rmFrizzled-8 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Frizzled-2 Antibody [DyLight 350]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Frizzled-2

Frizzled 2 is a receptor for Wnt proteins. Most of the frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of dishevelled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK3 kinase. Both pathways seem to involve interactions with G-proteins.

Alternate Names

Frizzled2, FZD2

Gene Symbol

FZD2

Additional Frizzled-2 Products

Product Documents for Frizzled-2 Antibody [DyLight 350]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Frizzled-2 Antibody [DyLight 350]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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