Catalog Number: 3103
Chemical Name: 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylic acid ester.
Biological Activity
Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.
Technical Data
  • M.Wt:
    721.83
  • Formula:
    C34H59NO15
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    116355-83-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.
    Merrill et al.
    J.Biol.Chem., 1993;268:27299
  2. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
    Blazquez et al.
    Cancer Res., 2008;68:1945
  3. Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin.
    Fukuda et al.
    Biochem.Biophys.Res.Comms., 1996;220:160

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