Mycotoxin produced by Fusarium moniliforme
. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50
~ 75 nM). Also inhibits protein phosphatases; IC50
values are 80, 300, 400, 500 and 3000 μ
M for PP5, PP2Cα
, PP2A, PP1γ
2 and PP2B respectively.
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.
Merrill et al.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Blazquez et al.
Cancer Res., 2008;68:1945
Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin.
Fukuda et al.