GABA-A R beta 3 Antibody

Novus Biologicals | Catalog # NBP1-06988

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
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Product Specifications

Immunogen

Peptide with sequence C-EKTAKAKNDRSK corresponding to internal region according to NP_068712.1.

Epitope

internal region

Specificity

This antibody is expected to recognize both reported isoforms (NP_000805.1, NP_068712.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GABA-A R beta 3 Antibody

Immunohistochemistry-Paraffin: GABA-A R beta 3 Antibody [NBP1-06988]

Immunohistochemistry-Paraffin: GABA-A R beta 3 Antibody [NBP1-06988]

Immunohistochemistry-Paraffin: GABA-A R beta 3 Antibody [NBP1-06988] - (2.5ug/ml) staining of Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for GABA-A R beta 3 Antibody

Application
Recommended Usage

Immunohistochemistry

2 - 4 ug/ml

Immunohistochemistry-Paraffin

2 - 4 ug/ml

Peptide ELISA

Detection limit 1:8000
Application Notes
WB: Preliminary experiments in human brain (cerebral cortex, frontal cortex and cerebellum) lysates gave no specific signal but low background. IHC-P: Human cortex shows patchy staining near or at the neuronal cell membrane.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GABA-A R beta 3

The GABRB3 gene encodes a member of the ligand-gated ionic channel family. The encoded protein, GABA A Receptor beta 3, is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. GABRB3 is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in the GABA A Receptor beta 3 gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism.

Long Name

gamma-Aminobutyric Acid Type A Receptor, beta-3 Polypeptide

Alternate Names

GABAAR beta 3, GABAARb3, GABRB3

Entrez Gene IDs

2562 (Human); 14402 (Mouse); 24922 (Rat)

Gene Symbol

GABRB3

Additional GABA-A R beta 3 Products

Product Documents for GABA-A R beta 3 Antibody

Certificate of Analysis

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Product Specific Notices for GABA-A R beta 3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Citations for GABA-A R beta 3 Antibody

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Protocols

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