Galanin R2/GALR2 Antibody

Novus Biologicals | Catalog # NB100-57081

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all Galanin R2/GALR2 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-RYPLHSRELRTPRN corresponding to internal region according to NP_003848.1.

Epitope

RYPLHSRELRTPRN

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Galanin R2/GALR2 Antibody

Western Blot: Galanin R2/GALR2 Antibody [NB100-57081]

Western Blot: Galanin R2/GALR2 Antibody [NB100-57081]

Western Blot: Galanin R2/GALR2 Antibody [NB100-57081] - (0.3ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Galanin R2/GALR2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000

Western Blot

0.3 - 1 ug/ml
Application Notes
WB: Approx. 40 kDa band observed in human heart lysates (calculated MW of 41.7 kDa band according to NP_003848.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Galanin R2/GALR2

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

Long Name

Galanin Receptor Type 2

Alternate Names

GAL2R, GalaninR2, GALNR2, GALR2

Entrez Gene IDs

8811 (Human); 14428 (Mouse); 29234 (Rat)

Gene Symbol

GALR2

UniProt

NP_003848.1 (Human)

Additional Galanin R2/GALR2 Products

Product Documents for Galanin R2/GALR2 Antibody

Certificate of Analysis

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Product Specific Notices for Galanin R2/GALR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Galanin R2/GALR2 Antibody

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