Catalog Number: 3424
Biological Activity
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Phe-11 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melanocortins and cardiovascular regulation.
    Versteeg et al.
    Eur.J.Pharmacol., 1998;360:1
  2. Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain.
    Lindblom et al.
    Brain Res., 1998;810:161
  3. Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats.
    Jansone et al.
    Neurosci.Lett., 2004;361:68

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