Biological Activityγ1-MSH is an endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
(Modifications: Phe-11 = C-terminal amide)
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Melanocortins and cardiovascular regulation.
Versteeg et al.
Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain.
Lindblom et al.
Brain Res., 1998;810:161
Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the DArgic mesolimbic system in rats.
Jansone et al.
Citation for γ1-MSH
The citations listed below are publications that use Tocris products. Selected citations for γ1-MSH include:
1 Citation: Showing 1 - 1
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
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