Biological ActivityEndogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
(Modifications: Phe-11 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Melanocortins and cardiovascular regulation.
Versteeg et al.
Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain.
Lindblom et al.
Brain Res., 1998;810:161
Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the DArgic mesolimbic system in rats.
Jansone et al.
Citation for γ1-MSH
The citations listed below are publications that use Tocris products. Selected citations for γ1-MSH include:
1 Citation: Showing 1 - 1
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
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