Biological ActivityGap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.
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Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries.
Chaytor et al.
Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts.
Ko et al.
Am.J.Physiol.Cell Physiol., 2000;279:C147
Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor.
Richards et al.
Citations for Gap 27
The citations listed below are publications that use Tocris products. Selected citations for Gap 27 include:
2 Citations: Showing 1 - 2
Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
Authors: Dosch Et al.
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Authors: Westphalen Et al.
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