The growth arrest-specific genes are related by their induction following cellular stress. Gas1 is a GPI-linked membrane glycoprotein that blocks entry to S phase cell cycle. Gas1 inhibits cell proliferation, protects endothelial cells from apoptosis, and promotes excitotoxic neuronal death. Gas6 is a vitamin K-dependent protein with a gamma-carboxylated amino terminus (Gla domain), four EGF-like repeats, and C-terminal globulin-like domains. Gas6 is a ligand for the Axl, Dtk, and Mer tyrosine kinase receptors. Gas6 is mitogenic and anti-apoptotic for some cell types and also promotes cell adhesion.
Gas1 Antibody (11C47) [CoraFluor™ 1]
Novus Biologicals | Catalog # NBP2-22032CL1
Key Product Details
Species Reactivity
Human
Applications
Western Blot, ELISA
Label
CoraFluor 1
Antibody Source
Monoclonal Rat IgG2 Clone # 11C47
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Product Specifications
Immunogen
Human recombinant Gas1
Clonality
Monoclonal
Host
Rat
Isotype
IgG2
Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(TM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
CoraFluor(TM) 1, amine reactive
CoraFluor(TM) 1, thiol reactive
For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
CoraFluor(TM) 1, amine reactive
CoraFluor(TM) 1, thiol reactive
For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
Scientific Data Images for Gas1 Antibody (11C47) [CoraFluor™ 1]
![Gas1 Antibody (11C47) [CoraFluor™ 1]](https://resources.rndsystems.com/images/products/nbp2-22032cl1_rat-gas1-mab-11c47-corafluor-1-710202517173020.png "Product Feature: CoraFluor Probes for TR-FRET")
Product Feature: CoraFluor Probes for TR-FRET
CoraFluor™ 1, amine reactive (Catalog:7920) and CoraFluor™ 2, amine reactive (Catalog # 7950) are terbium-based probes that have been developed for use as TR-FRET donors. They emit wavelengths compatible with commonly used fluorescent acceptor dyes such as BODIPY® (or BDY) and Janelia Fluor® dyes, FITC (Catalog # 5440), TMR and Cyanine 5 (Catalog # 5436). CoraFluor™ fluorescence is brighter and more stable in biological media than existing TR-FRET donors, leading to enhanced sensitivity and improved data generation. CoraFluor™ 1 exhibits excitation upon exposure to a 337 nm UV laser.Applications for Gas1 Antibody (11C47) [CoraFluor™ 1]
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein G purified
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark. Do not freeze.
Background: Gas1
Long Name
Growth-arrest-specific Protein 1
Alternate Names
GAS-1, growth arrest-specific 1, Growth arrest-specific gene-1, growth arrest-specific protein 1
Gene Symbol
GAS1
Additional Gas1 Products
Product Documents for Gas1 Antibody (11C47) [CoraFluor™ 1]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Gas1 Antibody (11C47) [CoraFluor™ 1]
CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- Western Blot Troubleshooting
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- View all Protocols, Troubleshooting, Illustrated assays and Webinars
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