Catalog Number: 0513
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride
Biological Activity
A very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
Technical Data
  • M.Wt:
    485.5
  • Formula:
    C28H32N2O.2HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    67469-75-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo.
    Bonnet and Constentin
    Eur.J.Pharmacol., 1986;121:199
  2. Cloning, pharmacological characterization and chromosome assignment of the human dopamine transporter.
    Giros et al.
    Mol.Pharmacol., 1992;42:383
  3. Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine.
    Do-Rego et al.
    J.Neurochem., 1999;72:396
  4. In vivo labelling of the neuronal dopamine uptake complex in the mouse striatum by [3H]GBR 12783.
    Vaugeois et al.
    Eur.J.Pharmacol., 1992;210:77
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GBR 12783 dihydrochloride include:

2 Citations: Showing 1 - 2
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  1. Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
    Authors: Ferreira Et al.
    J Pharmacol Exp Ther 2012;61:219
  2. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
    Authors: Ferraro Et al.
    Neuropsychopharmacology 2012;37:1856

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