GBR 12909 dihydrochloride

Tocris Bioscience | Catalog # 0421

Selective DA uptake inhibitor; also σ ligand
Tocris Bioscience

Key Product Details

Description

Selective DA uptake inhibitor; also σ ligand
View all Dopamine Transporter Inhibitors »

Product Description

GBR 12909 dihydrochloride is a potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has >100-fold lower affinity for the noradrenaline and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

Product Specifications for GBR 12909 dihydrochloride

Molecular Weight

523.49

Formula

C28H32F2N2O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

CAS Number

67469-78-7

PubChem ID

104920

InChI Key

MIBSKSYCRFWIRU-UHFFFAOYSA-N

SMILES

Cl.Cl.FC1=CC=C(C=C1)C(OCCN1CCN(CCCC2=CC=CC=C2)CC1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.62 5 with gentle warming
DMSO 26.17 50

Preparing Stock Solutions for GBR 12909 dihydrochloride

The following data is based on the product molecular weight 523.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.82 mL 19.10 mL 38.21 mL
2.5 mM 0.76 mL 3.82 mL 7.64 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
25 mM 0.08 mL 0.38 mL 0.76 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

Product Documents for GBR 12909 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GBR 12909 dihydrochloride

For research use only

Citations for GBR 12909 dihydrochloride

Customer Reviews for GBR 12909 dihydrochloride (1)

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  • GBR used as a selective DAT blocker for increasing dopamine release
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/15/2018
    GBR-12909 (300 nM) was used as a DAT blocker in slice voltametry experiments. It's difficult to get into solution. Just use some warming.
    GBR 12909 dihydrochloride 0421

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