Potent, competitive inhibitor of dopamine uptake (Ki
= 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50
= 48 nM). Centrally active following systemic administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The dopamine uptake inhibitor GBR12909: selectivity and molecular mechanism of action.
GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain.
Contreras et al.
Life Sci., 1990;47:PL133
Pharmacological characterization of the discriminative-stimulus effects of GBR 12909.
Spealman and Melia
Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake.
Heikkila and Manzino
The citations listed below are publications that use Tocris products. Selected citations for GBR 12909 dihydrochloride include:
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