GBR 12909 dihydrochloride

  ( 11 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0421
Chemical Name:1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Technical Data
  • M.Wt:
    523.49
  • Formula:
    C28H32F2N2O.2HCl
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    67469-78-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GBR 12909 dihydrochloride include:

11 Citations: Showing 1 - 10
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  1. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    Authors: Kim Et al.
    J Neurosci  2015;35:6307
  2. Dysfunctional dopaminergic neurotransmission in asocial BTBR mice.
    Authors: Squillace Et al.
    Transl Psychiatry  2014;4:e427
  3. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function α6* nAChRs.
    Authors: Wang Et al.
    J Neurochem  2014;129:315
  4. Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits.
    Authors: Patel Et al.
    PLoS One  2012;7:e41623
  5. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    J Neurosci  2012;37:321
  6. Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.
    Authors: Koprich Et al.
    PLoS One  2011;6:e17698
  7. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking.
    Authors: Navaroli Et al.
    J Neurosci  2011;31:13758
  8. Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pat
    Authors: Koprich Et al.
    Mol Neurodegener  2010;5:43
  9. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.
    Authors: Abdallah Et al.
    Br J Pharmacol  2009;29:8156
  10. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  11. PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.
    Authors: Visanji Et al.
    FASEB J  2008;22:2488
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Average Rating: 5 (Based on 1 review)

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Species Mouse
Pub Med ID 28115487

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