Catalog Number: 0514
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Biological Activity
Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex.
    Andersen et al.
    J.Neurochem., 1987;48:1887
  2. GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings.
    Reith et al.
    Eur.J.Pharmacol., 1994;253:175
  3. Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter.
    Reith et al.
    Eur.J.Pharmacol., 1992;227:417
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