GBR 12935 dihydrochloride
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Biological Activity
GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex.
Andersen et al.
J.Neurochem., 1987;48:1887 -
GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings.
Reith et al.
Eur.J.Pharmacol., 1994;253:175 -
Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter.
Reith et al.
Eur.J.Pharmacol., 1992;227:417
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for GBR 12935 dihydrochloride
There are currently no reviews for this product. Be the first to review GBR 12935 dihydrochloride and earn rewards!
Have you used GBR 12935 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
