GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-77042

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (93%). Backed by our 100% Guarantee.

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all GFR alpha-2/GDNF R alpha-2 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid peptide near the center of human GFR alpha 2. The immunogen is located within amino acids 360 - 410 of GFR alpha 2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free

Western Blot: GFR alpha-2/GDNF R alpha-2 AntibodyBSA Free [NBP1-77042]

Western Blot: GFR alpha-2/GDNF R alpha-2 AntibodyBSA Free [NBP1-77042]

Western Blot: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-77042] - HeLa total cell lysate with GDNF Receptor alpha 2 antibody at 1:1000 dilution.
GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free [NBP1-77042] -

Immunocytochemistry/ Immunofluorescence: GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free [NBP1-77042] - Immunocytochemistry of GFR alpha 2 in HeLa cells with GFR alpha 2 antibody at 5 ug/mL.

Applications for GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5 ug/ml

Western Blot

1 ug/ml
Application Notes
A 52 kDa band should be detected in Western Blot.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GFR alpha-2/GDNF R alpha-2

Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGFb related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa2 recently. GFRa2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha 2

Alternate Names

GDNF R alpha-2, GFR alpha2, GFRa-2, GFRA2

Gene Symbol

GFRA2

UniProt

AAC52036 (Human)

Additional GFR alpha-2/GDNF R alpha-2 Products

Product Documents for GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for GFR alpha-2/GDNF R alpha-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

GDNF Family

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Protocols

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FAQs

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