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Catalog Number:2430
Chemical Name:N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt
Product Details
Citations (1)
Reviews
Biological Activity
CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.
CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.
Technical Data
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M.Wt:593.66
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Formula:C27H33N3O3S.CF3CO2H
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Solubility:Soluble to 25 mM in DMSO
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Purity:>95
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Storage:Store at -20°C
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CAS No:1217457-86-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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Citations:
The citations listed below are publications that use Tocris products. Selected citations for GGTI 298 include:
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Average Rating: 5
(Based on 1 review)
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