GGTI 298

  ( 1 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2430
Chemical Name:N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt
Product Details
Citations (1)
Reviews
Biological Activity
CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.
Technical Data
  • M.Wt:
    593.66
  • Formula:
    C27H33N3O3S.CF3CO2H
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    1217457-86-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GGTI 298 include:

1 Citations: Showing 1 - 1

  1. Chenodeoxycholic Acid Requires Activation of EGFR, EPAC and Ca2+ to Stimulate CFTR-dependent Cl-Secretion in Human Colonic T84 Cells.
    Authors: Domingue Et al.
    American Journal of Physiology - Cell Physiology  2016;

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