GGTI 298

Tocris Bioscience | Catalog # 2430

Geranylgeranyltransferase I (GGTase I) inhibitor
Tocris Bioscience

Key Product Details

Description

Geranylgeranyltransferase I (GGTase I) inhibitor
View all Other Transferase Inhibitors »

Product Description

GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Product Specifications for GGTI 298

Molecular Weight

593.66

Formula

C27H33N3O3S.CF3CO2H

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt

CAS Number

1217457-86-7

PubChem ID

16078971

InChI Key

WALKWJPZELDSKT-UFABNHQSSA-N

SMILES

SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.84 25

Preparing Stock Solutions for GGTI 298

The following data is based on the product molecular weight 593.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 6.74 mL 33.69 mL 67.38 mL
1.25 mM 1.35 mL 6.74 mL 13.48 mL
2.5 mM 0.67 mL 3.37 mL 6.74 mL
12.5 mM 0.13 mL 0.67 mL 1.35 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 27 publications citing the usage of this product.

Product Documents for GGTI 298

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GGTI 298

For research use only

Customer Reviews for GGTI 298 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used GGTI 298?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Geranylgeranyltransferase I (GGTase I) inhibitor
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 03/26/2018
    Geranylgeranyltransferase I (GGTase I) inhibitor
    GGTI 298 2430

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All