CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50
values are 3 and > 10 μ
M respectively). Causes G0
cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.
Soluble to 25 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Platelet-derived growth factor receptor tyrosine kinase phosphorylation requires protein geranylgeranylation but not farnesylation.
McGuire et al.
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-227 causes G2-M enrichment in A549 cells.
Miquel et al.
Cancer Res., 1997;57:1846
A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics.
Porcu et al.
Selective inhibition of cancer cell invasion by a geranylgeranyltransferase inhibitor.
Kusama et al.
The citations listed below are publications that use Tocris products. Selected citations for GGTI 298 include:
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