GGTI 298

Catalog # Availability Size / Price Qty
2430/1
GGTI 298 | CAS No. 1217457-86-7 | Other Transferase Inhibitors
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Description: Geranylgeranyltransferase I (GGTase I) inhibitor

Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt

Purity: ≥95%

Product Details
Citations (1)
Reviews (1)

Biological Activity

CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Technical Data

M.Wt:
593.66
Formula:
C27H33N3O3S.CF3CO2H
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1217457-86-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Platelet-derived growth factor receptor tyrosine kinase phosphorylation requires protein geranylgeranylation but not farnesylation.
    McGuire et al.
    J.Biol.Chem., 1996;271:27402
  2. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-227 causes G2-M enrichment in A549 cells.
    Miquel et al.
    Cancer Res., 1997;57:1846
  3. A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics.
    Porcu et al.
    Mol.Cancer, 2010;9:197
  4. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase inhibitor.
    Kusama et al.
    Clin.Exp.Meta., 2003;20:561

Product Datasheets

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Citation for GGTI 298

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Geranylgeranyltransferase I (GGTase I) inhibitor
By Anonymous on 03/26/2018
Species: Rat

Geranylgeranyltransferase I (GGTase I) inhibitor


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