Catalog Number: 1465
Biological Activity
Endogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, it stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ser-3 = Ser(n-octanoyl))

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
This peptide is distributed under license from Dr. Kangawa
Background References
  1. Ghrelin: an orexigenic and somatotrophic signal from the stomach.
    Nat.Rev.Neurosci., 2001;2:551
  2. Ghrelin is growth-hormone-releasing acylated peptide from stomach.
    Kojima et al.
    Nature, 1999;402:656
  3. In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat.
    Tolle et al.
    Neuroendocrinology, 2001;73:54

The citations listed below are publications that use Tocris products. Selected citations for Ghrelin (rat) include:

Showing Results 1 - 10 of 14

  1. The�Anti-apoptotic�Effect�of�Ghrelin�on�Restraint�Stress-Induced�Thymus�Atrophy�in�Mice.
    Authors: Lee Et al.
    Immune Network
  2. Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
    Authors: Parent Et al.
    Int J Obes (Lond)
  3. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Adv Pharm Bull
  4. Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats.
    Authors: Bavil Et al.
    PLoS One
  5. Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats.
    Authors: Aliparasti Et al.
    Front Behav Neurosci
  6. Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin.
    Authors: Plasse Et al.
    Mol Metab
  7. Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis.
    Authors: Taati Et al.
    Nat Commun
  8. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
    Authors: Torres-Fuentes Et al.
    Adv Pharm Bull
  9. Ablation of AgRP neurons impairs adaption to restricted feeding.
    Authors: Tan Et al.
    Br J Pharmacol
  10. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    J Lab Autom
  11. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
    Authors: Schellekens Et al.
    J Biol Chem
  12. Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.
    Authors: Watterson Et al.
  13. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor.
    Authors: Thompson Et al.
    Iran J Reprod Med
  14. The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.
    Authors: Tucci Et al.
Expand to show all
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