Catalog Number: 1465
Biological Activity
Endogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, it stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
Technical Data
  • M.Wt:
    3314.83
  • Formula:
    C147H245N45O42
  • Sequence:
    GSSFLSPEHQKAQQRKESKKPPAKLQPR

    (Modifications: Ser-3 = Ser(n-octanoyl))

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    258338-12-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
This peptide is distributed under license from Dr. Kangawa
Background References
  1. Ghrelin: an orexigenic and somatotrophic signal from the stomach.
    Inu
    Nat.Rev.Neurosci., 2001;2:551
  2. Ghrelin is growth-hormone-releasing acylated peptide from stomach.
    Kojima et al.
    Nature, 1999;402:656
  3. In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat.
    Tolle et al.
    Neuroendocrinology, 2001;73:54
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ghrelin (rat) include:

14 Citations: Showing 1 - 10
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  1. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.
    Authors: Lee Et al.
    Immune Network 2016;16:242
  2. Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
    Authors: Parent Et al.
    Int J Obes (Lond) 2015;9:284
  3. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
    Authors: Bell Et al.
    Adv Pharm Bull 2015;6:7066
  4. Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats.
    Authors: Bavil Et al.
    PLoS One 2015;5:315
  5. Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats.
    Authors: Aliparasti Et al.
    Front Behav Neurosci 2015;5:195
  6. Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin.
    Authors: Plasse Et al.
    Mol Metab 2015;39:1742
  7. Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis.
    Authors: Taati Et al.
    Nat Commun 2015;13:85
  8. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
    Authors: Torres-Fuentes Et al.
    Adv Pharm Bull 2014;9:e103118
  9. Ablation of AgRP neurons impairs adaption to restricted feeding.
    Authors: Tan Et al.
    Br J Pharmacol 2014;3:694
  10. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    J Lab Autom 2013;38:1296
  11. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
    Authors: Schellekens Et al.
    J Biol Chem 2013;288:181
  12. Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.
    Authors: Watterson Et al.
    Neurosignals 2012;21:28
  13. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor.
    Authors: Thompson Et al.
    Iran J Reprod Med 2004;145:234
  14. The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.
    Authors: Tucci Et al.
    Neuropsychopharmacology 2004;143:520
Expand to show all 14 Citations

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