Biological ActivityEndogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, it stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
(Modifications: Ser-3 = Ser(n-octanoyl))
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Ghrelin: an orexigenic and somatotrophic signal from the stomach.
Ghrelin is growth-hormone-releasing acylated peptide from stomach.
Kojima et al.
In vivo and in vitro effects of ghrelin/motilin-related peptide on GH secretion in the rat.
Tolle et al.
Citations for Ghrelin (rat)
The citations listed below are publications that use Tocris products. Selected citations for Ghrelin (rat) include:
22 Citations: Showing 1 - 10
Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration.
Authors: May Et al.
J Neuroendocrinol 2018;:e12676
A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo.
Authors: Howick Et al.
Int J Mol Sci 2018;19
Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells.
Authors: Zeng Et al.
MRAP2 regulates ghrelin receptor signaling and hunger sensing.
Authors: Srisai Et al.
Nat Commun 2017;8:713
Central administration of ghrelin induces conditioned avoidance in rodents.
Authors: Schéle Et al.
Eur Neuropsychopharmacol 2017;27:809
The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice.
Authors: Lee Et al.
Immune Network 2016;16:242
Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents.
Authors: Schéle Et al.
PLoS One 2016;11:e0149456
Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
Authors: Parent Et al.
Int J Obes (Lond) 2015;9:284
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
Authors: Bell Et al.
Adv Pharm Bull 2015;6:7066
Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats.
Authors: Bavil Et al.
PLoS One 2015;5:315
Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats.
Authors: Aliparasti Et al.
Front Behav Neurosci 2015;5:195
Modulation of cue-induced firing of ventral tegmental area DA neurons by leptin and ghrelin.
Authors: Plasse Et al.
Mol Metab 2015;39:1742
Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis.
Authors: Taati Et al.
Nat Commun 2015;13:85
Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
Authors: Torres-Fuentes Et al.
Adv Pharm Bull 2014;9:e103118
Ablation of AgRP neurons impairs adaption to restricted feeding.
Authors: Tan Et al.
Br J Pharmacol 2014;3:694
Ghrelin decreases firing activity of gonadotropin-releasing hormone (GnRH) neurons in an estrous cycle and endocannabinoid signaling dependent manner.
Authors: Farkas Et al.
PLoS One 2013;8:e78178
Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
Authors: Romero-Picó Et al.
J Lab Autom 2013;38:1296
Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
Authors: Schellekens Et al.
J Biol Chem 2013;288:181
Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.
Authors: Watterson Et al.
Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype.
Authors: Burdyga Et al.
Am J Physiol Gastrointest Liver Physiol 2010;299:G63
Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor.
Authors: Thompson Et al.
Iran J Reprod Med 2004;145:234
The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin.
Authors: Tucci Et al.
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