Catalog Number: 1657
Alternate Names: BN 52021
Chemical Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Biological Activity
Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.
Technical Data
  • M.Wt:
    424.4
  • Formula:
    C20H24O10
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Storage:
    Desiccate at +4°C
  • CAS No:
    15291-77-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes.
    Foldes-Filep et al.
    Biochem.Biophys.Res.Commun., 1987;148:1412
  2. Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig.
    Desquand et al.
    Eur.J.Pharmacol., 1986;127:83
  3. The CNS effects of Ginkgo biloba extracts and ginkgolide B.
    Maclennan et al.
    Prog.Neurobiol., 2002;67:235
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ginkgolide B include:

1 Citations: Showing 1 - 1

  1. Protective effect of high concentration of BN52021 on retinal contusion in cat eyes.
    Authors: Huang Et al.
    Nat Neurosci 2015;15:50

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