Ginkgolide B
Chemical Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Biological Activity
Ginkgolide B is a platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig.
Desquand et al.
Eur.J.Pharmacol., 1986;127:83 -
Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes.
Foldes-Filep et al.
Biochem.Biophys.Res.Commun., 1987;148:1412 -
The CNS effects of Ginkgo biloba extracts and ginkgolide B.
Maclennan et al.
Prog.Neurobiol., 2002;67:235
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Citation for Ginkgolide B
The citations listed below are publications that use Tocris products. Selected citations for Ginkgolide B include:
1 Citation: Showing 1 - 1
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Protective effect of high concentration of BN52021 on retinal contusion in cat eyes.
Authors: Huang Et al.
Nat Neurosci 2015;15:50
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