Gly MCA

Catalog # Availability Size / Price Qty
6669/10
Cat.No. 6669 - Gly MCA | C26H43NO6 | CAS No. 66225-78-3
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Description: FXR antagonist; selectively active in intestines; orally bioavailable

Chemical Name: N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine

Product Details
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Biological Activity

Farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metabolic syndrome in obese mice. Orally bioavailable.

Technical Data

M.Wt:
465.62
Formula:
C26H43NO6
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Storage:
Store at -20°C
CAS No:
66225-78-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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